Breast cancer tumor grading

Histologic tumor grading
 can overstate the intermediate classification

Histologic tumor grade is a well-established prognostic factor for breast cancer recurrence and survival.^1,2 Histologic grade also has predictive value with respect to patient benefit from chemotherapy.² However, conventional histologic grading is a subjective assessment, with potential for both intra- and inter-observer variability. With this approach, approximately half of all breast cancers are classified as intermediate grade.

Molecular tumor grading with Breast Cancer Index^SM

Molecular tumor grading, through the Molecular Grade Index component of the Breast Cancer Index, has been demonstrated to provide an objective and robust assessment of tumor grade and proliferation.

References:
1. Cianfrocca M, Goldstein LJ: Prognostic and predictive factors in early-stage breast cancer. Oncologist, 9:606-616, 2004.
2. Schnitt SJ. Traditional and newer pathologic features. J Natl Cancer Inst Monogr., 22-26, 2001.